2-Pyridinecarboxylic acid, 5-[[(1,1-dimethylethoxy)carbonyl]amino]-
5-[(tert-Butoxycarbonyl)amino]-pyridine-2-carboxylic acid
CAS: 848308-47-4
Molecular Formula: C11H14N2O4
2-Pyridinecarboxylic acid, 5-[[(1,1-dimethylethoxy)carbonyl]amino]- - Names and Identifiers
2-Pyridinecarboxylic acid, 5-[[(1,1-dimethylethoxy)carbonyl]amino]- - Physico-chemical Properties
| Molecular Formula | C11H14N2O4 |
| Molar Mass | 238.24 |
| Density | 1.293±0.06 g/cm3(Predicted) |
| Boling Point | 356.5±27.0 °C(Predicted) |
| pKa | 1.02±0.50(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Sensitive | Irritant |
| MDL | MFCD09991768 |
2-Pyridinecarboxylic acid, 5-[[(1,1-dimethylethoxy)carbonyl]amino]- - Introduction
5-[(tert-Butoxycarbonyl)amino]-pyridine-2-carboxylic acid is a chemical substance that has the following properties:
1. Appearance: 5-[(tert-Butoxycarbonyl)amino]-pyridine-2-carboxylic acid is a white to pale yellow solid.
2. molecular formula: C13H17N3O4
3. Molecular weight: 279.3g/mol
4. melting point: about 145-148 degrees Celsius
5. Solubility: Soluble in common organic solvents (such as dimethylformamide and ethanol) and water.
5-[(tert-Butoxycarbonyl)amino]-pyridine-2-carboxylic acid is commonly used in protecting groups and intermediates in organic synthesis. Its main uses are as follows:
1. as a protecting group: 5-[(tert-Butoxycarbonyl)amino]-pyridine-2-carboxylic acid can be used as a protecting group for the amino group in amino compounds to prevent it from reacting with other reagents.
2. Synthesis of intermediates: It can be used as an important intermediate in organic synthesis and participate in complex organic reactions such as drug synthesis.
5-[(tert-Butoxycarbonyl)amino]-pyridine-2-carboxylic acid is generally prepared as follows:
1. First, 2-picolinic acid is obtained by reacting 2-picolinic acid with dimethylformamide diurea under alkali catalysis.
2. Next, 2-pyridinecarboxylic acid is reacted with tert-butoxycarbonyl isocyanate to produce 5-[(tert-Butoxycarbonyl) amino]-2-pyridinecarboxylic acid.
Regarding safety information, 5-[(tert-Butoxycarbonyl)amino]-pyridine-2-carboxylic acid is a chemical, and attention should be paid to safety protection measures during operation. Personal protective equipment, including laboratory gloves, safety glasses and laboratory clothing, is recommended for use. In addition, it should be operated in a well-ventilated environment to avoid contact with skin and inhalation of gases. If necessary, it is recommended to store in chemical storage cabinets and follow relevant regulations and regulations when storing and handling.
1. Appearance: 5-[(tert-Butoxycarbonyl)amino]-pyridine-2-carboxylic acid is a white to pale yellow solid.
2. molecular formula: C13H17N3O4
3. Molecular weight: 279.3g/mol
4. melting point: about 145-148 degrees Celsius
5. Solubility: Soluble in common organic solvents (such as dimethylformamide and ethanol) and water.
5-[(tert-Butoxycarbonyl)amino]-pyridine-2-carboxylic acid is commonly used in protecting groups and intermediates in organic synthesis. Its main uses are as follows:
1. as a protecting group: 5-[(tert-Butoxycarbonyl)amino]-pyridine-2-carboxylic acid can be used as a protecting group for the amino group in amino compounds to prevent it from reacting with other reagents.
2. Synthesis of intermediates: It can be used as an important intermediate in organic synthesis and participate in complex organic reactions such as drug synthesis.
5-[(tert-Butoxycarbonyl)amino]-pyridine-2-carboxylic acid is generally prepared as follows:
1. First, 2-picolinic acid is obtained by reacting 2-picolinic acid with dimethylformamide diurea under alkali catalysis.
2. Next, 2-pyridinecarboxylic acid is reacted with tert-butoxycarbonyl isocyanate to produce 5-[(tert-Butoxycarbonyl) amino]-2-pyridinecarboxylic acid.
Regarding safety information, 5-[(tert-Butoxycarbonyl)amino]-pyridine-2-carboxylic acid is a chemical, and attention should be paid to safety protection measures during operation. Personal protective equipment, including laboratory gloves, safety glasses and laboratory clothing, is recommended for use. In addition, it should be operated in a well-ventilated environment to avoid contact with skin and inhalation of gases. If necessary, it is recommended to store in chemical storage cabinets and follow relevant regulations and regulations when storing and handling.
Last Update：2024-04-09 21:01:54
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